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Article

The p. N103K mutation of leptin (LEP) gene and severe early onset obesity in Pakistan.

Biological research - 13 Apr 2016

Shabana, Hasnain Shahida

Abstract excerpt

BACKGROUND: Obesity is a complex disorder and has been increasing globally at alarming rates including Pakistan. However, there is scarce research on understanding obesity genetics in Pakistan. Leptin is a hormone secreted by adipocytes in response to satiety and correlates with body weight. Any mutations in the LEP gene have an adverse effect on energy regulation pathway and lead to severe, early onset obesity....

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Identifiers

PMID: 27075752
DOI: 10.1186/s40659-016-0082-7
PMCID: PMC4831177

Genes

LEP

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