Article

High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor

2023-03-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Biallelic pathogenic mutations in LEP, LEPR and MC4R genes controlling central leptin-melanocortin signalling cause early onset severe obesity. However, the long-term clinical outcomes of leptin signalling deficiency are unknown. <h4>DESIGN AND OBJECTIVES</h4> We carried out a retrospective cross-sectional clinical investigation of a large cohort of children with LEP, LEPR or...

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Literature Corpus work: 2e17c336-5cda-51cd-8e3d-6ee02a3e1d58
DOI: 10.1101/2023.03.09.23286793

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