Article
Understanding the Genetics of Early-Onset Obesity in a Cohort of Children From Qatar.
The Journal of clinical endocrinology and metabolism - 17 Nov 2023
Mohammed Idris, Haris Basma, Al-Barazenji Tara, Vasudeva Dhanya, Tomei Sara, Al Azwani Iman, Dauleh Hajar, Shehzad Saira, Chirayath Shiga, Mohamadsalih Ghassan, Petrovski Goran, Khalifa Amel, Love Donald R, Al-Shafai Mashael, Hussain Khalid
Abstract excerpt
CONTEXT: Monogenic obesity is a rare form of obesity due to pathogenic variants in genes implicated in the leptin-melanocortin signaling pathway and accounts for around 5% of severe early-onset obesity. Mutations in the genes encoding the MC4R, leptin, and leptin receptor are commonly reported in various populations to cause monogenic obesity. Determining the genetic cause has important clinical benefits as novel...
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