Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood Obesity

29 Apr 2022

Abstract excerpt

Monogenic obesity is a severe, genetically determined disorder that affects up to 1/1000 newborns. Recent reports on potential new therapeutics and innovative clinical approaches have highlighted the need for early identification of individuals with rare genetic variants that can alter the functioning of the leptin-melanocortin signalling pathway, in order to speed up clinical intervention and reduce the risk of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical Analysis and Sensing Techniques
Share to Pancreatic function and diabetes
Share to Regulation of Appetite and Obesity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35574020
DOI: 10.3389/fendo.2022.832911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood ObesityPMID 35574020Read ↗

Diagnostic Approach to Genetic Obesity in Children: From Pathophysiology to Precision MedicineSemantic proximity Read ↗

Targeted Next-Generation Sequencing of the Leptin-Melanocortin Pathway in Severe Obesity.Semantic proximity Read ↗

Updates on Rare Genetic Variants, Genetic Testing, and Gene Therapy in Individuals With Obesity.Semantic proximity Read ↗

Clinical and Biological Phenotypes of Patients Carrying a Heterozygous Variant in Genes of Leptin-Melanocortin Signaling Pathway.Semantic proximity Read ↗

Understanding the Genetics of Early-Onset Obesity in a Cohort of Children From Qatar.Semantic proximity Read ↗

The genetics of obesity: aetiology, prevention and therapy.Semantic proximity Read ↗

Genotype-Phenotype Spectrum of Non-Syndromic Monogenic Obesity in a National Paediatric Cohort.Semantic proximity Read ↗

The expanding landscape of genetic causes of obesity.Semantic proximity Read ↗

Updates on Monogenic Obesity in a Multifactorial Disease.Semantic proximity Read ↗

Screening of non-syndromic early-onset child and adolescent obese patients in terms of LEP, LEPR, MC4R and POMC gene variants by next-generation sequencing.Semantic proximity Read ↗

Sequencing methods, functional characterization, prevalence, and penetrance of rare coding mutations in panels of monogenic obesity genes from the leptin-melanocortin pathway: A systematic review.Semantic proximity Read ↗

Implication of Heterozygous Variants in Genes of the Leptin-Melanocortin Pathway in Severe Obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.