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Article

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB.

Nature - 13 May 2010

Scheuermann Johanna C, de Ayala Alonso Andrés Gaytán, Oktaba Katarzyna, Ly-Hartig Nga, McGinty Robert K, Fraterman Sven, Wilm Matthias, Muir Tom W, Müller Jürg

Abstract excerpt

Polycomb group (PcG) proteins are transcriptional repressors that control processes ranging from the maintenance of cell fate decisions and stem cell pluripotency in animals to the control of flowering time in plants. In Drosophila, genetic studies identified more than 15 different PcG proteins that are required to repress homeotic (HOX) and other developmental regulator genes in cells where they must stay...

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Source

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Identifiers

PMID: 20436459
DOI: 10.1038/nature08966
PMCID: PMC3182123

Genes

PRC1
BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB.PMID 20436459Read ↗

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Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila.Semantic proximity Read ↗

A genetic screen identifies novel polycomb group genes in Drosophila.Semantic proximity Read ↗

Knockdown of PR-DUB subunit <i>calypso</i> in the developing <i>Drosophila</i> eye and wing results in mis-patterned tissues with altered size and shapeSemantic proximity Read ↗

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