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Article

Dominant alleles identify SET domain residues required for histone methyltransferase of Polycomb repressive complex 2.

The Journal of biological chemistry - 10 Oct 2008

Joshi Preeti, Carrington Elizabeth A, Wang Liangjun, Ketel Carrie S, Miller Ellen L, Jones Richard S, Simon Jeffrey A

Abstract excerpt

Polycomb gene silencing requires histone methyltransferase activity of Polycomb repressive complex 2 (PRC2), which methylates lysine 27 of histone H3. Information on how PRC2 works is limited by lack of structural data on the catalytic subunit, Enhancer of zeste (E(Z)), and the paucity of E(z) mu...

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Identifiers

PMID: 18693240
DOI: 10.1074/jbc.M804442200
PMCID: PMC2562053

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18693240-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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