Article
Prediction of individual genetic risk to prostate cancer using a polygenic score.
The Prostate - 1 Sept 2015
Szulkin Robert, Whitington Thomas, Eklund Martin, Aly Markus, Eeles Rosalind A, Easton Douglas, Kote-Jarai Z Sofia, Amin Al Olama Ali, Benlloch Sara, Muir Kenneth, Giles Graham G, Southey Melissa C, Fitzgerald Liesel M, Henderson Brian E, Schumacher Fredrick, Haiman Christopher A, Schleutker Johanna, Wahlfors Tiina, Tammela Teuvo L J, Nordestgaard Børge G, Key Tim J, Travis Ruth C, Neal David E, Donovan Jenny L, Hamdy Freddie C, Pharoah Paul, Pashayan Nora, Khaw Kay-Tee, Stanford Janet L, Thibodeau Stephen N, McDonnell Shannon K, Schaid Daniel J, Maier Christiane, Vogel Walther, Luedeke Manuel, Herkommer Kathleen, Kibel Adam S, Cybulski Cezary, Lubiński Jan, Kluźniak Wojciech, Cannon-Albright Lisa, Brenner Hermann, Butterbach Katja, Stegmaier Christa, Park Jong Y, Sellers Thomas, Lin Hui-Yi, Lim Hui-Yi, Slavov Chavdar, Kaneva Radka, Mitev Vanio, Batra Jyotsna, Clements Judith A, Spurdle Amanda, Teixeira Manuel R, Paulo Paula, Maia Sofia, Pandha Hardev, Michael Agnieszka, Kierzek Andrzej, Gronberg Henrik, Wiklund Fredrik
Abstract excerpt
BACKGROUND: Polygenic risk scores comprising established susceptibility variants have shown to be informative classifiers for several complex diseases including prostate cancer. For prostate cancer it is unknown if inclusion of genetic markers that have so far not been associated with prostate cancer risk at a genome-wide significant level will improve disease prediction. METHODS: We built polygenic risk scores...
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