Article
A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact.
Genetic epidemiology - 1 Sept 2011
Macinnis Robert J, Antoniou Antonis C, Eeles Rosalind A, Severi Gianluca, Al Olama Ali Amin, McGuffog Lesley, Kote-Jarai Zsofia, Guy Michelle, O'Brien Lynne T, Hall Amanda L, Wilkinson Rosemary A, Sawyer Emma, Ardern-Jones Audrey T, Dearnaley David P, Horwich Alan, Khoo Vincent S, Parker Christopher C, Huddart Robert A, Van As Nicholas, McCredie Margaret R, English Dallas R, Giles Graham G, Hopper John L, Easton Douglas F
Abstract excerpt
Genome wide association studies have identified several single nucleotide polymorphisms (SNPs) that are independently associated with small increments in risk of prostate cancer, opening up the possibility for using such variants in risk prediction. Using segregation analysis of population-based samples of 4,390 families of prostate cancer patients from the UK and Australia, and assuming all familial aggregation...
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