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Article

Characterization of C69R variant HBsAg: effect on binding to anti-HBs and the structure of virus-like particles.

Archives of virology - 1 Oct 2015

Hadiji-Abbes Nadia, Mihoubi Wafa, Martin Marta, Karakasyan-Dia Carole, Frikha Fakher, Gergely Csilla, Jouenne Thierry, Gargouri Ali, Mokdad-Gargouri Raja

Abstract excerpt

Several variants of the major "a" determinant of the HBsAg, the main target of HBV neutralization by antibodies, have been described. However, mutations outside this region have not been as thoroughly investigated. During the genotyping of HBV from Tunisian patients with chronic hepatitis B, we identified a variant with a C69R substitution in the cytosolic loop of the S protein, resulting in a change in the...

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PMID: 26175067
DOI: 10.1007/s00705-015-2515-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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