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Article

In silico design of novel recombinant antigens containing immunologically relevant regions of wild-type and escape mutant variants of HBsAg.

PloS one - 1 Jan 2026

Workneh Yeshwas Abite, Sisay Desye Melese, Fekadu Abebaw, Bika Abraham Tesfaye, Mogus Alemu Tekewe, Sisay Tessema Tesfaye

Abstract excerpt

Hepatitis B virus (HBV) contributes substantially to liver cancer, related mortality, and liver transplantation worldwide. The small hepatitis B surface antigen (HBsAg), particularly its major hydrophilic region (MHR) and the "a" determinant, is the primary target of serological diagnostics. However, escape mutant amino acid variants (EMAVs) within this region may reduce diagnostic specificity and sensitivity. In...

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Identifiers

PMID: 41802005
DOI: 10.1371/journal.pone.0344362
PMCID: PMC12970925

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