Article
Molecular characterization of hepatitis B virus surface antigen mutants in Singapore patients with hepatocellular carcinoma and hepatitis B virus carriers negative for HBsAg but positive for anti-HBs and anti-HBc.
Journal of gastroenterology and hepatology - 1 Dec 2002
Oon Chong Jin, Chen Wei Ning, Goh Kee Tai, Mesenas Steven, Ng Han Seong, Chiang Gilbert, Tan Clarence, Koh Shiuan, Teng Siaw Wei, Toh Ivy, Moh Mei Chung, Goo Kian Sim, Tan Kaeling, Leong Ai Lin, Tan Gek San
Abstract excerpt
BACKGROUND AND AIMS: Mutations on the a-determinant of hepatitis B virus surface antigen (HBsAg), capable of escaping detection and vaccination, are identified in HBsAg-positive/anti-HBs-positive vaccinated infants. We studied the prevalence of these mutants in HBsAg-negative/anti-HBc-positive chronic HBV carriers and patients with hepatocellular carcinoma (HCC). METHODS: DNA sequence coding for the antigenic...
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