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Article

Construction and expression of hepatitis B surface antigen escape variants within the "a" determinant by site directed mutagenesis.

Iranian journal of immunology : IJI - 1 Sept 2013

Golsaz Shirazi Forough, Amiri Mohammad Mehdi, Mohammadi Hamed, Bayat Ali Ahmad, Roohi Azam, Khoshnoodi Jalal, Zarnani Amir Hassan, Jeddi-Tehrani Mahmood, Kardar Gholam Ali, Shokri Fazel

Abstract excerpt

BACKGROUND: The antibody response to hepatitis B surface antigen (HBsAg) controls hepatitis B virus infection. The "a" determinant of HBsAg is the most important target for protective antibody response, diagnosis and immunoprophylaxis. Mutations in this area may induce immune escape mutants and affect the performance of HBsAg assays. OBJECTIVES: To construct clinically relevant recombinant mutant forms of HBsAg...

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Identifiers

PMID: 24076590
DOI: 10.22034/iji.2013.16821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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