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Article

Self-organizing human cardiac microchambers mediated by geometric confinement

14 Jul 2015

Abstract excerpt

Tissue morphogenesis and organ formation are the consequences of biochemical and biophysical cues that lead to cellular spatial patterning in development. To model such events in vitro, we use PEG-patterned substrates to geometrically confine human pluripotent stem cell colonies and spatially present mechanical stress. Modulation of the WNT/β-catenin pathway promotes spatial patterning via geometric confinement...

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PMID: 26172574
DOI: 10.1038/ncomms8413

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