Article

Actin polymerization drives lumen formation in a human epiblast model

2023-04-20

Abstract excerpt

<h4>Summary</h4> Lumens or fluid-filled cavities are a ubiquitous feature of mammals and are often evolutionarily linked to the origin of body-plan complexity. Post-implantation, the pluripotent epiblast in a human embryo forms a central lumen, paving the way for gastrulation. While osmotic pressure gradients drive lumen formation in many developmental contexts, mechanisms of human epiblast lumenogenesis are unkn...

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Literature Corpus work: c2f13982-4fb1-54e0-a6e5-a01525f4b690
DOI: 10.1101/2023.04.20.537711

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