Article
A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease.
Journal of the American Society of Nephrology : JASN - 1 Apr 2020
Fan Fan, Geurts Aron M, Pabbidi Mallikarjuna R, Ge Ying, Zhang Chao, Wang Shaoxun, Liu Yedan, Gao Wenjun, Guo Ya, Li Longyang, He Xiaochen, Lv Wenshan, Muroya Yoshikazu, Hirata Takashi, Prokop Jeremy, Booz George W, Jacob Howard J, Roman Richard J
Abstract excerpt
BACKGROUND: The genes and mechanisms involved in the association between diabetes or hypertension and CKD risk are unclear. Previous studies have implicated a role for γ-adducin (ADD3), a cytoskeletal protein encoded by Add3. METHODS: We investigated renal vascular function in vitro and in vivo and the susceptibility to CKD in rats with wild-type or mutated Add3 and in genetically modified rats with...
Topics
- Animals
- Calmodulin-Binding Proteins
- Disease Models, Animal
- Homeostasis
- Hypertension
- Kidney Diseases
- Kidney Glomerulus
- Male
- Muscle, Smooth, Vascular