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Article

MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration.

Journal of the American Society of Nephrology : JASN - 1 Jan 2018

Cechova Sylvia, Dong Fan, Chan Fang, Kelley Michael J, Ruiz Phillip, Le Thu H

Abstract excerpt

Intronic variants of the MYH9 gene that encodes the nonmuscle myosin heavy chain IIA are associated with diabetic nephropathy in European Americans and with sickle cell disease-associated nephropathy. However, the causal functional variants of MYH9 have remained elusive. Rare missense mutations in MYH9 cause macrothrombocytopenia and are occasionally associated with development of nephropathy. The E1841K mutation...

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Identifiers

PMID: 28993503
DOI: 10.1681/ASN.2015060707
PMCID: PMC5748898

Genes

MYH9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration.PMID 28993503Read ↗

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Glomerular pathology in autosomal dominant MYH9 spectrum disorders: what are the clues telling us about disease mechanism?Semantic proximity Read ↗

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