Article
Monitoring PfMDR1 transport in Plasmodium falciparum.
Malaria journal - 15 Jul 2015
Reiling Sarah J, Rohrbach Petra
Abstract excerpt
BACKGROUND: The Plasmodium falciparum multidrug resistance 1 transporter, PfMDR1, contains five amino acid polymorphisms that are suggested to be involved in altered drug transport from the parasite's cytosol into the digestive vacuole (DV). Transport of a substrate into another intracellular compartment influences drug availability at its site of action, therefore making the parasite more susceptible or...
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