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Article

Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials.

ACS chemical biology - 20 Feb 2015

Flannery Erika L, McNamara Case W, Kim Sang Wan, Kato Tomoyo Sakata, Li Fengwu, Teng Christine H, Gagaring Kerstin, Manary Micah J, Barboa Rachel, Meister Stephan, Kuhen Kelli, Vinetz Joseph M, Chatterjee Arnab K, Winzeler Elizabeth A

Abstract excerpt

Aminopyrazoles are a new class of antimalarial compounds identified in a cellular antiparasitic screen with potent activity against Plasmodium falciparum asexual and sexual stage parasites. To investigate their unknown mechanism of action and thus identify their target, we cultured parasites in the presence of a representative member of the aminopyrazole series, GNF-Pf4492, to select for resistance. Whole genome...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25322084
DOI: 10.1021/cb500616x
PMCID: PMC4340351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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