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Article

Polymorphisms within PfMDR1 alter the substrate specificity for anti‐malarial drugs in<i>Plasmodium falciparum</i>

18 Aug 2008

Abstract excerpt

Resistance to several anti-malarial drugs has been associated with polymorphisms within the P-glycoprotein homologue (Pgh-1, PfMDR1) of the human malaria parasite Plasmodium falciparum. Pgh-1, coded for by the gene pfmdr1, is predominately located at the membrane of the parasite's digestive vacuole. How polymorphisms within this transporter mediate alter anti-malarial drug responsiveness has remained obscure....

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PMID: 18713316
DOI: 10.1111/j.1365-2958.2008.06413.x

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