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Article

Role of Different<i>Pf</i>crt and<i>Pf</i>mdr-1 Mutations in Conferring Resistance to Antimalaria Drugs in<i>Plasmodium falciparum</i>

11 Nov 2014

Abstract excerpt

Emergence of drugs resistant strains of Plasmodium falciparum has augmented the scourge of malaria in endemic areas. Antimalaria drugs act on different intracellular targets. The majority of them interfere with digestive vacuoles (DVs) while others affect other organelles, namely, apicoplast and mitochondria. Prevention of drug accumulation or access into the target site is one of the mechanisms that plasmodium...

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PMID: 25506039
DOI: 10.1155/2014/950424

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