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Article

PfMDR1: mechanisms of transport modulation by functional polymorphisms.

PloS one - 1 Jan 2011

Ferreira Pedro Eduardo, Holmgren Gabrielle, Veiga Maria Isabel, Uhlén Per, Kaneko Akira, Gil José Pedro

Abstract excerpt

ATP-Binding Cassette (ABC) transporters are efflux pumps frequently associated with multidrug resistance in many biological systems, including malaria. Antimalarial drug-resistance involves an ABC transporter, PfMDR1, a homologue of P-glycoprotein in humans. Twenty years of research have shown that several single nucleotide polymorphisms in pfmdr1 modulate in vivo and/or in vitro drug susceptibility. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21912647
DOI: 10.1371/journal.pone.0023875
PMCID: PMC3164660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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