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In vitro selection of Plasmodium falciparum drug-resistant parasite lines

18 Dec 2009

Abstract excerpt

The in vitro selection of antimicrobial resistance in important pathogens can provide critical information on the genetic basis of drug resistance, and such information can be used to predict, anticipate and even contain the spread of resistance in clinical practice. For instance, the discovery of the role of pfmdr1 in mefloquine resistance in malaria parasites resulted from in vitro studies. However, the in...

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PMID: 20022938
DOI: 10.1093/jac/dkp449

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