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Article

Detection of low-level DNA mutation by ARMS-blocker-Tm PCR.

Clinical biochemistry - 1 Feb 2016

Qu Shoufang, Liu Licheng, Gan Shuzhen, Feng Huahua, Zhao Jingyin, Zhao Jing, Liu Qi, Gao Shangxiang, Chen Weijun, Wang Mengzhao, Jiang Yongqiang, Huang Jie

Abstract excerpt

BACKGROUND: Low-level DNA mutations play important roles in cancer prognosis and treatment. However, most existing methods for the detection of low-level DNA mutations are insufficient for clinical applications because of the high background of wild-type DNA. DESIGN AND METHOD: In this study, a novel assay based on Tm-dependent inhibition of wild type template amplification was developed. The defining...

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PMID: 26169242
DOI: 10.1016/j.clinbiochem.2015.07.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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