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Article

Dilated Cardiomyopathy Associated With Deficiency of the Cytoskeletal Protein Metavinculin

7 Jan 1997

Abstract excerpt

BACKGROUND: The cytoskeleton plays an important role in maintaining cell structure and integrity. Defects in cytoskeletal proteins can cripple cell strength and may cause cardiomyopathy. We analyzed heart tissues from subjects with dilated cardiomyopathy for abnormalities in the cardiac cytoskeleton. Metavinculin, a cardiac isoform of the cytoskeletal protein vinculin, connects actin microfilaments to the...

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Share to Cardiac electrophysiology and arrhythmias
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Identifiers

PMID: 8994410
DOI: 10.1161/01.cir.95.1.17

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Related research

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Research trail→

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Dilated Cardiomyopathy Associated With Deficiency of the Cytoskeletal Protein MetavinculinPMID 8994410Read ↗

Metavinculin mutations alter actin interaction in dilated cardiomyopathy.Semantic proximity Read ↗

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A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy.Semantic proximity Read ↗

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Metavinculin Tunes the Flexibility and the Architecture of Vinculin-Induced Bundles of Actin Filaments.Semantic proximity Read ↗

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