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Article

Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy.

The American journal of pathology - 1 Sept 2004

Zemljic-Harpf Alice E, Ponrartana Sornya, Avalos Roy T, Jordan Maria C, Roos Kenneth P, Dalton Nancy D, Phan Vinh Q, Adamson Eileen D, Ross Robert S

Abstract excerpt

Vinculin and its muscle splice variant metavinculin link focal adhesions and cell-to-cell contact sites to the actin cytoskeleton. We hypothesized that normal expression of vinculin isoforms would be essential for integrity of cardiomyocytes and preservation of normal cardiac function. We studied heterozygous vinculin knockout mice (Vin+/-) that develop and breed normally. The Vin+/- mice displayed: 1) a 58%...

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Identifiers

PMID: 15331426
DOI: 10.1016/S0002-9440(10)63364-0
PMCID: PMC1618594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy.PMID 15331426Read ↗

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