Article
Loss of Elongation-Like Factor 1 Spontaneously Induces Diverse, RNase H-Related Suppressor Mutations in Schizosaccharomyces pombe.
Genetics - 1 Aug 2018
Marayati Bahjat F, Drayton Alena L, Tucker James F, Huckabee Reid H, Anderson Alicia M, Pease James B, Zeyl Clifford W, Zhang Ke
Abstract excerpt
A healthy individual may carry a detrimental genetic trait that is masked by another genetic mutation. Such suppressive genetic interactions, in which a mutant allele either partially or completely restores the fitness defect of a particular mutant, tend to occur between genes that have a confined functional connection. Here we investigate a self-recovery phenotype in Schizosaccharomyces pombe, mediated by...
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