Article
A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin.
Blood - 15 Jan 2005
D'Andrea Giovanna, D'Ambrosio Rosa Lucia, Di Perna Pasquale, Chetta Massimiliano, Santacroce Rosa, Brancaccio Vincenzo, Grandone Elvira, Margaglione Maurizio
Abstract excerpt
Patients require different warfarin dosages to achieve the target therapeutic anticoagulation. The variability is largely genetically determined, and it can be only partly explained by genetic variability in the cytochrome CYP2C9 locus. In 147 patients followed from the start of anticoagulation with warfarin, we have investigated whether VKORC1 gene mutations have affected doses of drug prescribed to acquire the...
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