Article
Prevalence of VKORC1 and CYP2C9 gene polymorphisms in Indian population and its effect on warfarin response.
The Journal of the Association of Physicians of India - 1 Dec 2012
Shalia Kavita K, Doshi Shripal M, Parikh Suhas, Pawar Poonam P, Divekar Siddhi S, Varma Sandeep P, Mehta Rachna, Doctor Tasneem, Shah Vinod K, Saranath D
Abstract excerpt
OBJECTIVES: The clinical effectiveness of Warfarin is established. Patients require different warfarin dosages to achieve the target therapeutic anticoagulation. The variability of Warfarin dosage is largely genetically determined, and it can be partly explained by the C1173T and G-1639A polymorphisms of vitamin K epoxide reductase complex subunit 1 (VKORC1) which is its target and *2 and *3 allele of Cytochrome...
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