Article

Hyperactive STAT1 Promotes T Follicular Helper Type 1 Cell Differentiation to Trigger Autoimmunity

2026-03-22

Abstract excerpt

<h4>ABSTRACTS</h4> Heterozygous gain-of-function (GOF) mutations in signal transducer and activator of transcription 1 ( STAT1 ) cause an inborn error of immunity characterized by immune dysregulation, recurrent infections and various autoimmune manifestations. However, the precise pathogenic mechanism by which STAT1 GOF contributes to autoimmunity remains elusive. In our cohort, STAT1 -GOF patients exhibit bi...

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Literature Corpus work: 0157c526-d871-53e7-950e-2198d197abba
DOI: 10.64898/2026.03.19.713058

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