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Article

Gain-of-function mutations and immunodeficiency: at a loss for proper tuning of lymphocyte signaling.

Current opinion in allergy and clinical immunology - 1 Dec 2015

Arjunaraja Swadhinya, Snow Andrew L

Abstract excerpt

PURPOSE OF REVIEW: To present recent advances in the discovery and characterization of new immunodeficiency disorders linked to gain-of-function (GOF) mutations in immune signaling molecules. (Figure is included in full-text article.) RECENT FINDINGS: In the past 2 years, extensive cellular and molecular studies have illuminated the root causes of pathogenesis for several new monogenic primary immunodeficiency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunologic Deficiency Syndromes

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Source

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Identifiers

PMID: 26406182
DOI: 10.1097/ACI.0000000000000217
PMCID: PMC4672729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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