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Article

Toll-Like Receptor 4 Wild Type Homozygozity of Polymorphisms +896 and +1196 Is Associated with High Gastrin Serum Levels and Peptic Ulcer Risk.

PloS one - 1 Jan 2015

Pohjanen Vesa-Matti, Koivurova Olli-Pekka, Huhta Heikki, Helminen Olli, Mäkinen Johanna M, Karhukorpi Jari M, Joensuu Tapio, Koistinen Pentti O, Valtonen Jarno M, Niemelä Seppo E, Karttunen Riitta A, Karttunen Tuomo J

Abstract excerpt

Toll-like receptor 4 is a part of the innate immune system and recognizes Helicobacter pylori lipopolysaccharide. The goal of this study was to analyze the role of Toll-like receptor 4 polymorphisms +896 (rs4986790) and +1196 (rs4986791) in the pathogenesis of Helicobacter pylori related gastroduodenal diseases in relation to gastric secretion and inflammation. Toll-like receptor 4 polymorphisms, serum gastrin-17...

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Identifiers

PMID: 26161647
DOI: 10.1371/journal.pone.0131553
PMCID: PMC4498789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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