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Article

Polymorphisms in TLR9 but not in TLR5 increase the risk for duodenal ulcer and alter cytokine expression in the gastric mucosa.

Innate immunity - 1 Oct 2015

Trejo-de la O Alejandra, Torres Javier, Sánchez-Zauco Norma, Pérez-Rodríguez Martha, Camorlinga-Ponce Margarita, Flores-Luna Lourdes, Lazcano-Ponce Eduardo, Maldonado-Bernal Carmen

Abstract excerpt

Colonization of the gastric mucosa by Helicobacter pylori can lead to peptic ulcer and gastric adenocarcinoma. TLRs are signaling receptors involved in the recognition of microorganisms, and polymorphisms in their genes may influence the innate and adaptive immune response to H. pylori, affecting the clinical outcomes of the infection. We assessed the association between single nucleotide polymorphisms in TLR9...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25995217
DOI: 10.1177/1753425915587130

Genes

TLR9
TLR5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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