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PTEN regulates DNA replication progression and stalled fork recovery

9 Jul 2015

Abstract excerpt

Faithful DNA replication is a cornerstone of genomic integrity. PTEN plays multiple roles in genome protection and tumour suppression. Here we report on the importance of PTEN in DNA replication. PTEN depletion leads to impairment of replication progression and stalled fork recovery, indicating an elevation of endogenous replication stress. Exogenous replication inhibition aggravates replication-originated DNA...

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PMID: 26158445
DOI: 10.1038/ncomms8620

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