Article
PTEN as a Guardian of the Genome: Pathways and Targets.
Cold Spring Harbor perspectives in medicine - 1 Sept 2020
Fan Xinyi, Kraynak Jeffrey, Knisely Jonathan P S, Formenti Silvia C, Shen Wen H
Abstract excerpt
Faithful transmission of genetic information is only possible with the structural and functional integrity of the genome. PTEN has been recognized as a guardian of the genome since the identification of its noncanonical localization and function in the nucleus. Yet, the role of PTEN in guarding the genome relies on integration of diverse mechanisms elicited by its canonical activity in antagonizing PI3K as well...
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