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Article

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.

Nucleic acids research - 12 Oct 2018

Hjorth-Jensen Kim, Maya-Mendoza Apolinar, Dalgaard Nanna, Sigurðsson Jón O, Bartek Jiri, Iglesias-Gato Diego, Olsen Jesper V, Flores-Morales Amilcar

Abstract excerpt

Mutations in SPOP, the gene most frequently point-mutated in primary prostate cancer, are associated with a high degree of genomic instability and deficiency in homologous recombination repair of DNA but the underlying mechanisms behind this defect are currently unknown. Here we demonstrate that SPOP knockdown leads to spontaneous replication stress and impaired recovery from replication fork stalling. We show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30124983
DOI: 10.1093/nar/gky719
PMCID: PMC6182143

Genes

SPOP
RAD51
ATR
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.PMID 30124983Read ↗

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