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Article

SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.

Nature communications - 1 Oct 2021

Ma Jian, Shi Qing, Cui Gaofeng, Sheng Haoyue, Botuyan Maria Victoria, Zhou Yingke, Yan Yuqian, He Yundong, Wang Liguo, Wang Yuzhuo, Mer Georges, Ye Dingwei, Wang Chenji, Huang Haojie

Abstract excerpt

Geminin and its binding partner Cdt1 are essential for the regulation of DNA replication. Here we show that the CULLIN3 E3 ubiquitin ligase adaptor protein SPOP binds Geminin at endogenous level and regulates DNA replication. SPOP promotes K27-linked non-degradative poly-ubiquitination of Geminin at lysine residues 100 and 127. This poly-ubiquitination of Geminin prevents DNA replication over-firing by indirectly...

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Identifiers

PMID: 34599168
DOI: 10.1038/s41467-021-26049-6
PMCID: PMC8486843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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