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Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

1 Dec 2016

Abstract excerpt

Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced replication (BIR) for damaged DNA replication forks. To better understand BIR, we performed a targeted siRNA screen for genes whose depletion inhibited G1 to S phase progression when oncogenic cyclin E was overexpressed. RAD52, a gene dispensable for...

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PMID: 27984746
DOI: 10.1016/j.molcel.2016.10.038

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