Article
HLA-B*38:02:01 predicts carbimazole/methimazole-induced agranulocytosis.
Clinical pharmacology and therapeutics - 1 May 2016
Cheung C-L, Sing C-W, Tang C S M, Cheng V K F, Pirmohamed M, Choi C-H, Hung C-S, Lau E Y-F, Lee K F, Mak M W-H, Leung J Y Y, Wong T-W, Ho A Y Y, Chan K-W, Hung Vhf, Tam V, Siu S-C, Pang H-K, Wat W Z-M, Lee H H-Y, Chung C-T, Hue R S-M, Sham P-C, Cheung B M Y, Wong I C K, Tan K C B, Kung A W C
Abstract excerpt
Thioamides antithyroid-drugs (ATDs) are important in hyperthyroid disease management. Identification of the susceptibility locus of ATD-induced agranulocytosis is important for clinical management. We performed a genome-wide association study (GWAS) involving 20 patients with ATD-induced agranulocytosis and 775 healthy controls. The top finding was further replicated. A single-nucleotide polymorphism (SNP),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.