Article

Analysis of Glomerular Transcriptomes from Nephrotic Patients Suggest<i>APOL1</i>Risk Variants Impact Parietal Epithelial Cells

2024-11-05

Abstract excerpt

<h4>ABSTRACT</h4> The disproportionate risk for idiopathic proteinuric podocytopathies in Black people is explained, in part, by the presence of two risk alleles (G1 or G2) in the APOL1 gene. The pathogenic mechanisms responsible for this genetic association remain incompletely understood. We analyzed glomerular RNASeq transcriptomes from patients with idiopathic nephrotic syndrome of which 72 had inferred African...

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Literature Corpus work: 1404f682-37e0-55ed-a3c6-a962bbc5a587
DOI: 10.1101/2024.11.05.24316766

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