Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology.

The Proceedings of the Nutrition Society - 1 Feb 2004

Crabb David W, Matsumoto Michinaga, Chang David, You Min

Abstract excerpt

Alcohol dehydrogenase (ADH) and mitochondrial aldehyde dehydrogenase (ALDH2) are responsible for metabolizing the bulk of ethanol consumed as part of the diet and their activities contribute to the rate of ethanol elimination from the blood. They are expressed at highest levels in liver, but at lower levels in many tissues. This pathway probably evolved as a detoxification mechanism for environmental alcohols....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Dehydrogenase
Share to Alcoholism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Aldehyde Dehydrogenase

Share to Aldehyde Dehydrogenase, Mitochondrial

Share to Ethanol

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Intestinal Absorption

Source

Identifiers

PMID: 15099407
DOI: 10.1079/pns2003327

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology.PMID 15099407Read ↗

The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants.Semantic proximity Read ↗

Role of ALDH2 in Hepatic Disorders: Gene Polymorphism and Disease PathogenesisSemantic proximity Read ↗

Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical ReviewSemantic proximity Read ↗

Genetic Associations of Alcohol and Aldehyde Dehydrogenase With Alcohol Dependence and Their Mechanisms of ActionSemantic proximity Read ↗

Aldehyde Dehydrogenase, Liver Disease and CancerSemantic proximity Read ↗

Genes encoding enzymes involved in ethanol metabolismSemantic proximity Read ↗

Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.Semantic proximity Read ↗

Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease.Semantic proximity Read ↗

Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.Semantic proximity Read ↗

Alcohol metabolism and cancer risk.Semantic proximity Read ↗

Alcohol dehydrogenase: enzymology and metabolism.Semantic proximity Read ↗

Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.