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Article

ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles

4 Jul 2019

Abstract excerpt

Background & Aims Excessive alcohol consumption is one of the major causes of hepatocellular carcinoma (HCC). Approximately 30–40% of the Asian population are deficient for aldehyde dehydrogenase 2 (ALDH2), a key enzyme that detoxifies the ethanol metabolite acetaldehyde. However, how ALDH2 deficiency affects alcohol-related HCC remains unclear. Methods ALDH2 polymorphisms were studied in 646 patients with viral...

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PMID: 31279903
DOI: 10.1016/j.jhep.2019.06.018

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