Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment

11 Feb 2021

Abstract excerpt

A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and tumorigenesis/growth/metastasis has been widely reported. Either low or high ALDH2 expression contributes to tumor progression and varies among different tumor types. Furthermore, the ALDH2∗2 polymorphism (rs671) is the most common single nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Hepatocellular Carcinoma Treatment and Prognosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Liver Disease Diagnosis and Treatment

Source

Identifiers

PMID: 34221859
DOI: 10.1016/j.apsb.2021.02.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatmentPMID 34221859Read ↗

ALDH2 gene polymorphism in different types of cancers and its clinical significance.Semantic proximity Read ↗

Role of ALDH2 in Hepatic Disorders: Gene Polymorphism and Disease PathogenesisSemantic proximity Read ↗

Aldehyde Dehydrogenase, Liver Disease and CancerSemantic proximity Read ↗

Advances in Factors Affecting ALDH2 Activity and its Mechanisms.Semantic proximity Read ↗

The Significance of Aldehyde Dehydrogenase 1 in CancersSemantic proximity Read ↗

Molecular Characterization and Clinical Relevance of ALDH2 in Human CancersSemantic proximity Read ↗

Effect of ALDH2 polymorphism on cancer risk in AsiansSemantic proximity Read ↗

Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.Semantic proximity Read ↗

ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory MechanismSemantic proximity Read ↗

ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.Semantic proximity Read ↗

Genetic Polymorphisms of the Mitochondrial Aldehyde Dehydrogenase ALDH2 Gene in a Large Ethnic Hakka Population in Southern China.Semantic proximity Read ↗

Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.