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Cell adhesion molecule pathway genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer's disease brains.

Neurobiology of aging - 1 Oct 2015

Bao Xinjie, Liu Gengfeng, Jiang Yongshuai, Jiang Qinghua, Liao Mingzhi, Feng Rennan, Zhang Liangcai, Ma Guoda, Zhang Shuyan, Chen Zugen, Zhao Bin, Wang Renzhi, Li Keshen, Liu Guiyou

Abstract excerpt

We previously identified the cell adhesion molecule (CAM) pathway as a consistent signal in 2 Alzheimer's disease (AD) genome-wide association studies (GWAS). However, the genetic mechanisms of the CAM pathway in AD are unclear. Here, we conducted pathway analysis using (1) Kyoto Encyclopedia of Genes and Genomes and Gene Ontology pathways; (2) 4 brain expression GWAS datasets; and (3) 2 whole-genome AD...

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PMID: 26149918
DOI: 10.1016/j.neurobiolaging.2015.06.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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