Article
Systematic pathway enrichment analysis of a genome-wide association study on breast cancer survival reveals an influence of genes involved in cell adhesion and calcium signaling on the patients' clinical outcome.
PloS one - 1 Jan 2014
Woltmann Andrea, Chen Bowang, Lascorz Jesús, Johansson Robert, Eyfjörd Jorunn E, Hamann Ute, Manjer Jonas, Enquist-Olsson Kerstin, Henriksson Roger, Herms Stefan, Hoffmann Per, Hemminki Kari, Lenner Per, Försti Asta
Abstract excerpt
Genome-wide association studies (GWASs) may help to understand the effects of genetic polymorphisms on breast cancer (BC) progression and survival. However, they give only a focused view, which cannot capture the tremendous complexity of this disease. Therefore, we investigated data from a previously conducted GWAS on BC survival for enriched pathways by different enrichment analysis tools using the two main...
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