Article
Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility.
Molecular systems biology - 10 Mar 2016
Piccolo Stephen R, Hoffman Laura M, Conner Thomas, Shrestha Gajendra, Cohen Adam L, Marks Jeffrey R, Neumayer Leigh A, Agarwal Cori A, Beckerle Mary C, Andrulis Irene L, Spira Avrum E, Moos Philip J, Buys Saundra S, Johnson William Evan, Bild Andrea H
Abstract excerpt
The signaling events that drive familial breast cancer (FBC) risk remain poorly understood. While the majority of genomic studies have focused on genetic risk variants, known risk variants account for at most 30% of FBC cases. Considering that multiple genes may influence FBC risk, we hypothesized that a pathway-based strategy examining different data types from multiple tissues could elucidate the biological...
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