Article
Promoter variant rs2301228 on the neural cell adhesion molecule 1 gene confers risk of schizophrenia in Han Chinese.
Schizophrenia research - 1 Dec 2014
Zhang Wen, Xiao Mei-Sheng, Ji Shuang, Tang Jinsong, Xu Ling, Li Xiao, Li Ming, Wang Hui-Zhen, Jiang Hong-Yan, Zhang Deng-Feng, Wang Jicai, Zhang Shuliang, Xu Xiu-Feng, Yu Li, Zheng Ping, Chen Xiaogang, Yao Yong-Gang
Abstract excerpt
BACKGROUND: Schizophrenia is recognized as a disorder of the brain and neuronal connectivity. The neural cell adhesion molecule 1 (NCAM1) gene plays a crucial role in regulating neuronal connectivity. METHODS: We conducted a two-stage association analysis on 17 NCAM1 SNPs in two independent Han Chinese schizophrenia case-control cohorts (discovery sample from Hunan Province: 986 patients and 1040 normal controls;...
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