Article
A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients.
Progress in neuro-psychopharmacology & biological psychiatry - 10 Jan 2013
Supriyanto Irwan, Watanabe Yuichiro, Mouri Kentaro, Shiroiwa Kyoichi, Ratta-Apha Woraphat, Yoshida Masakuni, Tamiya Genki, Sasada Toru, Eguchi Noriomi, Okazaki Kenji, Shirakawa Osamu, Someya Toshiyuki, Hishimoto Akitoyo
Abstract excerpt
BACKGROUND: Cell adhesion molecules (CAMs) play pivotal role in the development of the central nervous system (CNS) and have also been reported to play role in the pathophysiology of schizophrenia. Missense mutations in the CAMs genes might alter the binding of their ligands, increasing the vulnerability to develop schizophrenia. METHODS: We selected 15 missense mutations in the CAMs genes of the CNS reported in...
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