Article

A Bayesian approach to mediation analysis predicts 206 causal target genes in Alzheimer’s disease

2017-11-14

Abstract excerpt

Characterizing the intermediate phenotypes, such as gene expression, that mediate genetic effects on complex diseases is a fundamental problem in human genetics. Existing methods utilize genotypic data and summary statistics to identify putative disease genes, but cannot distinguish pleiotropy from causal mediation and are limited by overly strong assumptions about the data. To overcome these limitations, we devel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9eb1da63-d6f7-5b15-977a-65596963d093
DOI: 10.1101/219428

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Bayesian approach to mediation analysis predicts 206 causal target genes in Alzheimer’s diseaseDOI 10.1101/219428Read

A Bayesian model selection approach to mediation analysis.Semantic proximity Read

A mediation analysis framework based on variance component to remove genetic confounding effect.Semantic proximity Read

Powerful large scale inference in high dimensional mediation analysis.Semantic proximity Read

PRISM-xQTL: Pleiotropic Relationships Integrated with System-level Multiomic QTL analysis for causal genes and molecular mediators in Alzheimer's disease.Semantic proximity Read

MELODY: Mediation Analysis in Logistic Regression for High-Dimensional Mediators and a Binary OutcomeSemantic proximity Read

A Bayesian model selection approach to mediation analysisSemantic proximity Read

Shared Causal Paths underlying Alzheimer’s dementia and Type 2 DiabetesSemantic proximity Read

Generalized multi-SNP mediation intersection-union test.Semantic proximity Read

Heterogeneous causal mediation analysis using Bayesian additive regression trees.Semantic proximity Read

Metabolites mediate genetic effects on disease in the Canadian Longitudinal Study on AgingSemantic proximity Read

Partitioning gene-mediated disease heritability without eQTLs.Semantic proximity Read

Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysisSemantic proximity Read