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Integrating Genome-Wide Association Study and Brain Expression Data Highlights Cell Adhesion Molecules and Purine Metabolism in Alzheimer's Disease.

Molecular neurobiology - 1 Aug 2015

Xiang Zimin, Xu Meiling, Liao Mingzhi, Jiang Yongshuai, Jiang Qinghua, Feng Rennan, Zhang Liangcai, Ma Guoda, Wang Guangyu, Chen Zugen, Zhao Bin, Sun Tiansheng, Li Keshen, Liu Guiyou

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. Recently, genome-wide association studies (GWAS) have been used to investigate AD pathogenesis. However, a large proportion of AD heritability has yet to be explained. We previously identified the cell adhesion molecule (CAM) pathway as a consistent signal in two AD GWAS. However, it is unclear whether CAM is present in the...

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PMID: 25204495
DOI: 10.1007/s12035-014-8884-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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