Article
A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility.
Genes and immunity - 1 Mar 2014
Damotte V, Guillot-Noel L, Patsopoulos N A, Madireddy L, El Behi M, De Jager P L, Baranzini S E, Cournu-Rebeix I, Fontaine B
Abstract excerpt
Genome-wide association studies (GWASs) perform per-SNP association tests to identify variants involved in disease or trait susceptibility. However, such an approach is not powerful enough to unravel genes that are not individually contributing to the disease/trait, but that may have a role in interaction with other genes as a group. Pathway analysis is an alternative way to highlight such group of genes. Using...
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